"Magic Mike" was stripped of the top spot at the box office by a debaucherous teddy bear, as "Ted" dominated ticket sales at the multiplex this weekend.

"Ted," an R-rated raunchfest from "Family Guy" creator Seth MacFarlane, debuted with a strong $54.1 million, according to an estimate from distributor Universal Pictures. "Magic Mike," loosely based on star Channing Tatum's own experience as a stripper, also overperformed with a robust opening of $39.2 million.

Meanwhile, Tyler Perry's "Madea's Witness Protection" — the filmmaker's first movie to hit theaters during the summer — launched with a solid $26.4 million. But the adult drama "People Like Us," starring Chris Pine and Elizabeth Banks, flopped upon its debut with a weak $4.3 million.

Photos: If 'Magic Mike' is the 'Citizen Kane' of stripper movies ...

There has never before been a weekend in which two R-rated films grossed more than $21 million apiece, but "Ted" and "Magic Mike" managed the feat. Each film capitalized on a different audience: "Ted" appealed to men, as 56% of its crowd was male. And "Magic Mike," which also features beefcakey stars such as Matthew McConaughey and Joe Manganiello, lured in a 73% female audience.

"Ted," which stars Mark Wahlberg as a man whose best friend is his potty-mouthed teddy bear, was well-liked by moviegoers, who assigned it an average grade of A-, according to market research firm CinemaScore. With strong word of mouth, the film should end up being a much-needed hit for Universal Pictures, which is coming off the moderate performance of "Snow White and the Huntsman" and the disastrous box-office showing for the pricey "Battleship." "Ted" was acquired by Universal and Relativity Media, but was financed by Media Rights Capital for $50 million.

Steven Soderbergh's "Magic Mike" earned the best critical reviews of any of the weekend's new releases, and audiences seemed happy with it as well, assigning the movie a B+ grade. Even if the film were not to do solid business in the coming weeks, its already a win for Warner Bros., which acquired the independently financed $7-million production.

Dan Fellman, the studio's president of domestic distribution, said the film played like its 2008 film "Sex and the City," reeling in large groups of women to theaters on Friday evening. Part of the movie's allure was newly minted box-office draw Tatum, who has appeared in two hits this year: The romantic drama "The Vow" and the comedy "21 Jump Street."

The film stars Pine as a man whose father dies and leaves him with $150,000 to give to a long-lost sister, played by Elizabeth Banks. The directorial debut from "Transformers" screenwriter Alex Kurtzman, "People Like Us" did best with an older audience — 58% of whom were over the age of 35.

The movie, which received a B+ CinemaScore, did especially well in the heartland, selling 152% more tickets than usual in Salt Lake City. Dave Hollis, Disney's executive vice president of distribution, said he was hopeful that adult moviegoers would discover the film in the coming weeks.

“This movie appeals to an audience that doesn’t always rush out to see a movie on its first night,” Hollis said. “This was always meant to be a counterprogramming choice for a more discerning adult audience, and for them to have an intelligent option seemed important.”

In limited release, Fox Searchlight's "Beasts of the Southern Wild" grossed a robust $169,236. Playing in four theaters, that amounted to a per-location average of $42,309 — the third-highest average of the year, behind Wes Anderson's "Moonrise Kingdom" and Woody Allen's "To Rome With Love." The critically beloved drama, about a girl trying to learn to be self-sufficient in a Louisiana bayou as her father dies, has scored top prizes at major film festivals such as Cannes. 

[Updated, 12:05 p.m. July 1: "Men in Black 3" continued its impressive performance overseas, raking in an additional $6.4 million abroad this weekend. The movie has now sold $599.4 million in tickets worldwide, and has officially made more than the original "Men in Black" movie did in 1997 — not adjusting for inflation. That first installment in the franchise made $589.4 million 15 years ago.

Here are the top 10 movies at the domestic box office, with international results when available, according to studio estimates and Rentrak:

1. "Ted" (Universal/Relativity/MRC): Opened with $54.1 million. $2.8 million overseas in one foreign market.

2. "Magic Mike" (Warner Bros.): Opened with $39.2 million.

3. "Brave" (Disney): $34 million on its second weekend, down 49%. Domestic total: $131.7 million. $6.7 million overseas in 11 foreign markets. International total: $26.8 million.

4. "Tyler Perry's Madea's Witness Protection" (Lionsgate): Opened with $26.4 million.

5. "Madagascar 3: Europe's Most Wanted" (Paramount/DreamWorks Animation): $11.8 million on its fourth weekend, down 40%. Domestic total: $180 million. $16.2 million overseas in 44 foreign countries. International total: $244.2 million.

6. "Abraham Lincoln: Vampire Hunter" (Fox): $6 million on its second weekend, down 63%. Domestic total: $29 million. $5 million overseas in 21 foreign markets. International total: $17.5 million.

7. "Prometheus" (Fox): $4.9 on its fourth weekend, down 50%. Domestic total: $118.3 million. $6.2 million overseas in 58 foreign markets. International total: $166.5 million.

8. "Moonrise Kingdom" (Focus Features): $4.9 million on its sixth weekend, up 44%. Domestic total: $18.4 million.

9. "Snow White and the Huntsman" (Universal): $4.4 million on its fifth weekend, down 46%. Domestic total: $145.6 million. $14.5 million overseas in 60 foreign markets. International total: $189 million.

10. "People Like Us" (Disney/DreamWorks): Opened with $4.3 million.]